backBack to 3/2015
Technical Issues
3/2015 pp. 11-17

Właściwości i zastosowanie pochodnych 2H-1-benzopiran-2-onu jako związków pochodzenia naturalnego

pdf Get full text pdf


This article is a detailed literature overview about properties and wide application of coumarin derivatives, whose representative is 2H-1-benzopyran-2-one. It turns out that this compounds can be found in many places all around the world. Huge part of them is already isolated and synthesized in laboratory conditions, however there are assumptions that many of them are not known at all and they might have an influence on science development. Considering to the structural variety of coumarin, its derivatives are characterized by different properties, what reflects numerous possibilities of their application and also attracts the interest of the world of science.

Key words

coumarin, 2H-1-benzopyran-2-one, furanocoumarin, pyranocoumarin


1. Venugopala, K.N., Rashmi, V., Odhav, B., Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity, BioMed Research International, 2013, pp. 1-15.

2. Paullink, K., The Discovery of Dicumarol and Its Sequels, Circulation, 1959, pp. 97-107.

3. Lacy, A., O’Kennedy, R., Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer, Current Pharmaceutical Design, 2004, pp. 3797-3811.

4. Keating, G., O’Kennedy, R., The Chemistry and Occurrence of Coumarins. Coumarins: Biology, Applications and Mode of Action, John Wiley & Sons, Chichester, 1997.

5. Murray, R.D.H., Mendez, J., Brown, R.A., The Natural Coumarins, John Wiley & Sons, 1982.

6. Choi, J., Lee, K.T., Ka, H., Jung, W.T., Jung H.J., Park, H.J., Constituents of the essential oil of the Cinnamomum cassiastem bark and the biological properties, Archives of Pharmacal Research, 2001, pp. 418–423.

7. Bye. A., King, H.K., The Biosynthesis of 4-Hydroxycoumarin and Dicoumarol by Aspergillus fumigatus Fresenius, Biochem. J., 1970, 117, pp. 237-245.

8. Wu, L, Wang, X., Xu, W., Farzaneh, F., Xu, R., 2009. The structure and pharmacological functions of coumarins and their derivatives, Curr. Med. Chem., 2009, 6(32), pp. 4236-4260.

9. Fylaktakidou, K.C., Hadjipavlou-Litina, D.J., Litinas, K.E., Nicolaides, D.N., Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities, Current Pharmaceutical Design, 2004, 10(30), pp. 3813-3833. 

10. Kwon, O.S., Choi, J.S., Islam, M.N., et al., Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents, Archives of Pharmacal Research, 2011. pp. 34(9), pp. 1561-1569.

11. Iranshahi, M.,, Askari, M., Sahebkar, A., Hadjipavlou-Litina, D., Evaluation of antioxidant, anti-inflammatory and lipoxygenase inhibitory activities of the prenylated coumarin umbelliprenin, DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 2009, pp. 99-103.

12. Au N., Rettie A.E., Pharmacogenomics of 4-Hydroxycoumarin Anticoagulants, Drug metabolism review, 2008, 40(2), pp. 355-375.

13. Patil, A.D., Freyer, A.J., Eggleston D.S., et al., The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn, Journal of Medicinal Chemistry, 1993, 36(26), pp. 4131–4138.

14. Chiang, C.C., Cheng, M.J., Peng, C.F., Huang, H.Y., Chen, I.S., 2010. Anovel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa, Chemistry and Biodiversity, 2010, 7(7), pp. 1728-1736.